CPT 45121
Removal of rectum and colon
CPT 45121 at a glance
- Code
- 45121
- Code type
- CPT/HCPCS (Add. EE)
- Short descriptor
- Removal of rectum and colon
- Category
- Excluded from ASC Pay (Add. EE)
- ASC payment status
- Excluded from ASC payment
- CMS addendum
- EE (Excluded)
- Typical setting
- Hospital outpatient department (POS 22) or office (POS 11). Not separately payable in an ASC.
What is CPT code 45121?
CPT 45121 is a CPT/HCPCS (Add. EE) procedure code. Its official CMS short descriptor is "Removal of rectum and colon". In the ASC context it is grouped under Excluded from ASC Pay (Add. EE).
Is CPT 45121 payable in an ambulatory surgery center (ASC)?
CPT 45121 is on CMS Addendum EE, the list of procedures excluded from ASC payment. Medicare does not pay for it in the ASC setting; it is typically performed in a hospital outpatient department (HOPD) or office instead.
Where is CPT 45121 typically performed?
Hospital outpatient department (POS 22) or office (POS 11). Not separately payable in an ASC.
Which specialties use CPT 45121?
CPT 45121 is most associated with Gastroenterology, General Surgery.
Reference information compiled from the CMS April 2026 ASC payment addenda (AA, BB, EE). Codes, descriptors, and ASC payment status change with each CMS update. This is a coding reference, not billing, coding, or legal advice. Always verify against the current CMS addenda and individual payer policy before billing. CPT is a registered trademark of the American Medical Association.