CPT 45378
Diagnostic colonoscopy
Last reviewed August 2026 · DataLily AI data team
What does CPT 45378 mean?
CPT 45378 reports a diagnostic colonoscopy — a flexible endoscopic examination of the entire colon — including collection of specimens by brushing or washing when performed. When a biopsy or other intervention is performed, a therapeutic code such as 45380 is reported instead.
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CPT 45378 at a glance
- Code
- 45378
- Code type
- CPT/HCPCS
- Short descriptor
- Diagnostic colonoscopy
- Category
- ASC Surgical
- ASC eligibility
- ASC-eligible (surgical)
- Typical setting
- Ambulatory surgery center (POS 24) or hospital outpatient department (POS 22).
- Medicare ASC rate
- $510.49 national · 2026Q2
What is CPT code 45378?
CPT 45378 reports a diagnostic colonoscopy — a flexible endoscopic examination of the entire colon — including collection of specimens by brushing or washing when performed. When a biopsy or other intervention is performed, a therapeutic code such as 45380 is reported instead. Its official short descriptor is "Diagnostic colonoscopy", and in the ASC context it is grouped under ASC Surgical.
Is CPT 45378 eligible in an ambulatory surgery center (ASC)?
CPT 45378 can be performed in a certified ambulatory surgery center.
Where is CPT 45378 typically performed?
Ambulatory surgery center (POS 24) or hospital outpatient department (POS 22).
What is the Medicare ASC payment rate for CPT 45378?
The national Medicare ASC payment rate for CPT 45378 is $510.49 (Medicare ASC Payment System, 2026Q2). This is the national, unadjusted Medicare amount; the amount an individual ambulatory surgery center is paid is adjusted for local wage index and may differ. It reflects Medicare's facility payment only and does not include the surgeon's professional fee.
Which specialties use CPT 45378?
CPT 45378 is most associated with Gastroenterology, General Surgery.
Reference information about ASC eligibility and typical procedure setting. Codes, descriptors, and ASC-eligibility status change over time. This is a coding reference, not billing, coding, or legal advice. Always verify against current guidance and individual payer policy before scheduling or billing. CPT is a registered trademark of the American Medical Association. Read the DataLily AI data methodology.