CPT 45380
Colonoscopy and biopsy
CPT 45380 at a glance
- Code
- 45380
- Code type
- CPT/HCPCS
- Short descriptor
- Colonoscopy and biopsy
- Category
- ASC Surgical
- ASC eligibility
- ASC-eligible (surgical)
- Typical setting
- Ambulatory surgery center (POS 24) or hospital outpatient department (POS 22).
- Medicare ASC rate
- $656.75 national · 2026Q2
What is CPT code 45380?
CPT 45380 is a CPT/HCPCS procedure code. Its official short descriptor is "Colonoscopy and biopsy". In the ASC context it is grouped under ASC Surgical.
Is CPT 45380 eligible in an ambulatory surgery center (ASC)?
CPT 45380 can be performed in a certified ambulatory surgery center.
Where is CPT 45380 typically performed?
Ambulatory surgery center (POS 24) or hospital outpatient department (POS 22).
What is the Medicare ASC payment rate for CPT 45380?
The national Medicare ASC payment rate for CPT 45380 is $656.75 (CMS ASC Payment System, 2026Q2). This is the national, unadjusted amount published by CMS; the amount an individual ambulatory surgery center is paid is adjusted for local wage index and may differ. It reflects Medicare's facility payment only and does not include the surgeon's professional fee.
Which specialties use CPT 45380?
CPT 45380 is most associated with Gastroenterology, General Surgery.
Reference information about ASC eligibility and typical procedure setting. Codes, descriptors, and ASC-eligibility status change over time. This is a coding reference, not billing, coding, or legal advice. Always verify against current guidance and individual payer policy before scheduling or billing. CPT is a registered trademark of the American Medical Association.